Upon binding to the type II IFN receptor, IFN-γ triggers the JAK/STAT signalling cascade that leads to the expression of a large array of interferon induced genes which can cause growth arrest, cell death or make tumour cells to upregulate MHC-I expression and antigen presentation, thus becoming more susceptible to MHC-restricted cytolytic killing24, 25. This evidence concerns the gene IFNG and neoplasm.