For example, in addition to modulating the activity of deacetylase SIRT1 in an AMPK-dependent manner in breast cancer cells (Ferrer et al., 2017), OGT-mediated O-GlcNAcylation can also affect cancer cell growth and invasion through regulating the oncogenic transcription factor FOXM1 (Caldwell et al., 2010), suggesting the interplay of O-GlcNAcylation and SIRT1 in cancer cells. This evidence concerns the gene OGT and breast cancer.