More importantly, TET genes, especially TET2 are frequently mutated in various cancers, including myelodysplastic syndrome (MDS), cohort of chronic myelomonocytic leukemia (CMML), primary and secondary AML, blastic plasmacytoid dendritic neoplasm (Scourzic et al., 2015; Delhommeau et al., 2009; Langemeijer et al., 2009; Tefferi et al., 2009). The gene discussed is TET2; the disease is chronic myelomonocytic leukemia.