In 5-fluorouracilresistant colon cancer cells (SNUC5/5-FUR), highly expressed OGT binds to TET1 and recruits to the Nrf2 (nuclear factor erythroid 2-related factor 2) promoter region, suggesting the role of OGT in TET1-mediated Nrf2 expression (Kang et al., 2016). This evidence concerns the gene NFE2L2 and colonic neoplasm.