We have, however, shown that (1) AML cells secrete factors that stimulate other cells as well as autostimulate the AML cells themselves (2) The stimulation by AML cell conditioned medium correlates with the basal high affinity degradation rate in the AML cells directly after isolation from blood, and (3) The concentrations of in particular IL-6 and IL-8 in the conditioned media correlated with the basal LDL degradation rates. Here, CXCL8 is linked to acute myeloid leukemia.