We have previously shown that FAB subgroups M4 and M5 are characterized by the highest LDL degradation rate compared to FAB-M1-3 and acute lymphoblastic leukemia [2] which is in agreement with reports showing that TNF-α, IL-6, IL-8, and IL-18 are over-expressed and secreted in these subgroups. Here, TNF is linked to acute lymphoblastic leukemia.