Considering that incubation of cells with cytokines and mitogenic substances have been shown to stimulate LDL receptor gene expression and cause sterol resistance [13, 15, 18–22], we hypothesized that leukemic cells from AML patients synthesize cytokines/growth factors that autostimulate LDL uptake and cause decreased responsiveness to sterols. Here, LDLR is linked to acute myeloid leukemia.