Notably, our patient's adenoma had the USP8 p.P720R mutation that has previously been described as involved in the pathogenesis of CD (Ma et al. 2015; Reincke et al. 2015), occurring in 35%–62% of CD-causing corticotroph adenomas (Perez-Rivas and Reincke 2016); this was also the sole mutation identified in the ClinVar cross-reference. This evidence concerns the gene USP8 and adenoma.