TP53 and prostate adenocarcinoma: The induction of neuroendocrine transformation in adenocarcinoma of the prostate is recognized and is associated with loss of tumor-suppressor genes (such as TP53, which was mutated in this case), loss of androgen-related pathways, and activation of mitotic pathways such as aurora kinase A thought to play significant roles (Li et al. 2013; Vlachostergios and Papandreou 2015).