It has been reported that the plasma levels of several leukocyte- and endothelial cell-expressed, ADAM17 substrates are significantly elevated during sepsis, including L-selectin, ICAM-1, VCAM-1, CD16b, TNFα, IL-6R, TNFRI, and TNFRII, and some of these substrates demonstrated a positive correlation with disease severity (Ertel et al., 1994; Muller Kobold et al., 1998; Schulte et al., 2013; Zonneveld et al., 2014; Lerman and Kim, 2015). This evidence concerns the gene TNF and Sepsis.