The study established cutoffs with considerable predictive and diagnostic value for Tb with pleural effusions: 4000 pg/mL for IL-6 (sensitivity: 90.6%; specificity: 76.5%), 4 pg/mL for TNF-α (sensitivity: 90.6%; specificity: 79.4%), and 60 pg/mL for IFN-γ (sensitivity: 100%; specificity: 100%). This evidence concerns the gene TNF and Pleural effusion.