Optimal cutoffs for diagnosing active forms of lupus nephritis using IL-6 and IL-17 were 12.3 pg/mL (AUC 93%) and 19.7 pg/mL (AUC 95%), respectively, whereas optimal cutoffs for diagnosing lupus nephritis in remission were higher, at 20.8 pg/mL (AUC 80%) and 27 pg/mL (AUC 82%), respectively. Here, IL6 is linked to lupus nephritis.