IFNG and Pleural effusion: Most recently, Shu et al. (2015) proposed that IFN-γ cannot be used alone and demonstrated that, in order to improve the IFN-γ model, DcR3 and TNF-sR1 should be included when developing an ROC curve for predicting Tb pleural effusion, suggesting that additional factors must be considered when using cytokines as diagnostic tools [25].