ORAI1 and skin aging: (+)-Valencene was reported to significantly inhibit the activity of transient receptor potential ankyrin-1 (TRPV1) and calcium release-activated calcium modulator 1 (ORAI1), which are critical in mediating UV-induced skin aging, thus this natural product is suggested to be a potent candidate for the development of therapeutic agents for the prevention and treatment of UV-induced photoaging (Nam et al., 2016).