COPS5 and infection: By comparing the TLR3/TLR4-related subnetworks generated from acute and chronic stages of infection, we found several nodes (including LY96, TLR1, TLR4, IRAK1, MAPK3, MAP3K7, BRCA1, NFKBIB, COPS5, and JUN) that were consistently involved in both subnetworks (Figure 2), suggesting that these DEG may play a consistent role in regulation of TLR3/TLR4 function during F. hepatica infection.