MYD88 and infection: In the network representing the acute stage of infection, five pathways associated with TLR3/TLR4 signaling were ranked in the top 10 overlapping pathways identified, including “TLR4 cascade,” “activated TLR4 signaling,” “TRIF-mediated TLR3/TLR4 signaling,” “MyD88-independent cascade,” and “TLR3 cascade” (Table 2).