In animal model studies, knockout-mice void of LGI1 expression developed lethal epilepsy or neuronal hyperexcitability (47–49), zebrafish with knockdown of LGI1 showed a seizure-like behavior (50), LGI1-mutant rats expressing a missense mutation replicated the spontaneous epileptic syndromes in human (51), and cats with feline temporal lobe epilepsy were thought to be caused by an immune-mediated process, which had been confirmed to be related to LGI1 antibodies (52). This evidence concerns the gene LGI1 and temporal lobe epilepsy.