(c) Suppression of SOCE by an Orai1 inhibitor RO2959, Orai1-siRNAs, or STIM1-siRNAs all attenuated the phenylephrine-induced hypertrophy, demonstrating a critical role of SOCE, STIM1 and Orai1 in promoting cardiac hypertrophy. The gene discussed is STIM1; the disease is cardiac hypertrophy.