MAPT and Alzheimer disease: However, some resting-state studies comparing different MCI groups have also detected a specific hypersynchronization pattern in high frequency bands (alpha and beta) in those MCI subjects who finally developed AD (López et al., 2014a), or those who presented abnormal concentration of phospho-tau (p-tau) protein in the cerebrospinal fluid (CSF; Canuet et al., 2015).