BDNF and infarction: Our previous study using 7T MR neuroimaging and neurotrophin analyses in rat MCA occlusion model22 found the neuroprotective effect of BNG-1 may act through recovery of cerebral hemodynamics, decrease of infarction size and edema, reduction of postischemic hyperperfusion injury and recovery of neurotrophn-3 and brain-derived neurotrophic factor.