In addition, other brain abnormalities, such as those commonly observed in the rodent models of MKS3, for example exencephaly, meningocoele and hydrocephalus in the rat (Wpk) and mouse (eg bpck) models of MKS37, 9, 26–29, were absent in the affected lambs. The gene discussed is TMEM67; the disease is Hydrocephalus.