Prevalence of distinct subset of CD8+ Treg cells are reported in colon cancer (CD8+CD25+FOXP3+ cells), prostate cancer (CD25+CD122+FOXP3+ and partly GITR+ cells), non-small cell lung cancer (CD8+CD28− cells) and in ovarian cancer (CD8+CCR7+IL10+ cells)3–6. Here, CD8A is linked to malignant colon neoplasm.