Oncogene gene set enrichment analysis comparing the EPCAM+CD44+CD49f+ cells to the bulk tumor regions enriched for gene sets related to PTEN, KRAS, and BRCA1 in the bulk tumor, while gene sets associated with KRAS synthetic lethality (STK33 and TBK1), differentiation (HOXA9 and RPS14), and cAMP signaling were enriched in EPCAM+CD44+CD49f+ cells (Supplementary Figure 3). This evidence concerns the gene ITGA6 and neoplasm.