ITGA6 and neoplasm: To verify that the EPCAM+CD44+CD49f+ cells isolated from the lymph nodes were cancer cells derived from the primary tumor as well as to examine intratumoral genetic diversity, we performed whole-exome sequencing of bulk tumor samples, lymph nodes, and EPCAM+CD44+CD49f+ cells from each region generating 1,931,478,798 total reads which were aligned to the UCSC hg19 reference genome.