CD44 and neoplasm: Somatic variants present in both the bulk tumor and tumor EPCAM+CD44+CD49f+ subpopulations were categorized as shared (37/51, 72.5%), enriched in the bulk tumor (5/51, 9.8%), or enriched in the tumor EPCAM+CD44+CD49f+ cells (9/51, 17.6%) (Figure 2A).