Disrupted CRY2 and PER2 are associated with non-Hodgkin’s lymphoma [18] and the initiation and/or progression of AML [35], respectively, and CpG islands of PER3 are highly methylated in all patients with chronic myelogenous leukemia [36]. This evidence concerns the gene PER3 and chronic myelogenous leukemia, BCR-ABL1 positive.