To gain clinical significance, using The Cancer Genomic Atlas (TCGA) breast cancer cohort, we dichotomized 1082 breast cancer subjects into two groups based on the expression of the seven genes (ALDH1B1, ASTL, CA7, CPLX4, KCNV2, MAGEE2 and TUBA3E). The gene discussed is CPLX4; the disease is breast cancer.