BHLHE40 and viral infectious disease: In addition to direct interaction with the Bcl6 locus (Ogbe et al., 2015), we found that Egr2 directly bound to the Myc, Myb, Tcf7, Id3, Ascl2, and Lef1 loci, genes that were down-regulated in Egr2- and Egr3-deficient T cells, and also to the Bhlhe40, Rora, Rorc, and Zeb2 loci, which were up-regulated in Egr2- and Egr3-deficient T cells in response to viral infection (Fig. 8, B and D).