CD2-Egr2/3−/− mice had severe inflammatory pathology in the lungs after i.n. infection with OVA-VVWR (Fig. 2 G), whereas lung inflammation and mononucleocyte infiltration in infected lungs were much milder in CD2-Egr2 transgenic mice compared with WT counterparts (Fig. 2 G). This evidence concerns the gene CD2 and infection.