Consistent with the results from CD2-Egr2/3−/− mice, Egr2/3-deficient retrogenic OT1 cells had severe defects in proliferation but were highly activated and produced excessive levels of effector cytokines compared with WT retrogenic-OT1 cells in response to OVA-VVWR infection (Fig. 4, D–G). The gene discussed is CD2; the disease is infection.