To investigate the genes regulated by Egr2 and 3 in Egr2-expressing T cells in infected mice in vivo, CD44highGFP-Egr2high CD4 and CD8 cells from GFP-Egr2 mice and CD44high CD4 and CD8 T cells from CD2-Egr2/3−/− mice were isolated after viral infection and analyzed by RNA-seq. The gene discussed is EGR2; the disease is viral infectious disease.