Also targeted therapy has recently emerged in TET management and the use of EGFR-tyrosine kinase inhibitors (TKI) (Erlotinib or Gefitinib) or anti-EGFR mAb (Cetuximab) are currently under investigation as potential therapeutic agents in TET, especially in patients with heavily pretreated thymoma [12, 23, 64–66]. The gene discussed is EGFR; the disease is thymoma.