CEACAM5 and colorectal carcinoma: Univariate analysis revealed male sex (P = 0.045), a primary CRC with N2 disease (P = 0.007), identification of vascular invasion by the primary CRC (P = 0.018), a serum CEA ≥ 5.0 ng/mL before lung metastasectomy (P = 0.026), and a DFI < 24 months after CRC resection (P = 0.026) as significant risk factors for recurrence (Table 1).