TYMS and frontotemporal dementia: Although TS inhibition by FTD‐MP may partly account for the antitumor effects of FTD (Santi and Sakai, 1971; Temmink et al., 2004), the incorporation of FTD‐TP into DNA and the resulting DNA damage appear to be the major mechanism of action of FTD (Tanaka et al., 2014; Suzuki et al., 2011; Matsuoka et al., 2015).