AKT1 and neoplasm: EGFR tyrosine kinase activation stimulates the key processes in tumor growth and progress via activation of downstream signaling pathways, including RAS/RAF (rapidly accelerated fibrosarcoma) kinase/mitogen‐activated protein kinase (MAPK) kinase (MEK)/extracellular signal‐regulated kinase (ERK), phosphatidylinositol 3‐kinase (PI3K)–protein kinase B (also known as AKT), and signal transducer and activator of transcription (STAT) pathways (Yarden and Sliwkowski, 2001; Scaltriti and Baselga, 2006; Hynes and Lane, 2005).