Although signaling mediated by collagen I – the major component of extracellular matrix – has been demonstrated to increase the clonogenic capacity of pancreatic tumor cells under treatment with 5‐FU, allowing chemoresistant clones to grow out (Armstrong et al., 2004), we did not observe an enhancement of the efficacy of gemcitabine and paclitaxel following the ablation of SPOCK1. The gene discussed is SPOCK1; the disease is pancreatic neoplasm.