To experimentally confirm that indeed SPOCK1 is expressed in tumor‐instructed stromal cells, we cocultured an immortalized human pancreatic stellate cell line (PS‐1; Froeling et al., 2009) with a previously established PDAC cell lines (PANC‐1 and MIA PaCa‐2) as well as a primary patient‐derived tumor cell line established in our laboratory (67; Damhofer et al., 2015). This evidence concerns the gene SPOCK1 and neoplasm.