Importantly in the past fewyears, hif-1α has been implicated in the development of a range ofliver pathologies, such as liver fibrosis, activation of the immune system,hepatocellular carcinoma, and others, in humans, as well as in rodents (Nath and Szabo, 2012, Semenza, 2012). This evidence concerns the gene HIF1A and hepatocellular carcinoma.