Among the 10 cytokines, the concentrations of IL-6, IL-7, IL-8, IFN-γ, PIGF-1, VEGF-A, β-NGF, HGF, EGF and FGF-2 were significantly higher in the AH of patients with RB than the control group (P<0.05). The gene discussed is IL6; the disease is retinoblastoma.