In our study, we discovered that intraocular concentrations of IL-6, IL-7, IL-8, PIGF-1, IFN-γ, HGF, β-NGF, FGF-2 and VEGF-A were significantly higher in RB patients than in the CTR group, while IP-10 showed the opposite. This evidence concerns the gene FGF2 and retinoblastoma.