APPL1 and neoplasm: For instance, most common gene losses at 3p14.3 of APPL1, SLMAP and ASB14 present in 15/26 G1 and 11/20 G3 tumours (Fisher’s exact test p-values of p = 1) differ from gene losses of genes such as CCDC66 and ARHGEF3 present in 19 and 22 tumours assigned to Fuhrman grade G1 in 15 and 16 cases, respectively (Fisher’s exact test p-values of p<0.0055 and p<0.0071, Table A in S4 File).