CNAs of all 48 HRO tumour genomes were mapped to the PI3K pathway (Fig 7) in comparison to corresponding CNAs derived from individual ccRCC genomes specified by ccRCC G1_365 (S13 Fig 1) and by ccRCC G3_287 (Fig. B in S12 File). Here, PIK3CB is linked to nonpapillary renal cell carcinoma.