Six top-ranked pathways representing most abundant gene gains and losses were PI3K-Akt Signaling Pathway (264/364 genes), Pathway in Cancer (251/327 genes), Neuroactive-Ligand-Receptor-Interactions (208/275 genes), MicroRNAs in Cancer (202/296 genes), MAPK Signaling Pathway (191/259 genes) and Cytokine-Cytokine Receptor Interactions (185/265 genes), see Table D in S1 File. The gene discussed is AKT1; the disease is cancer.