Renal Cell Carcinoma Pathway (Table I in S2 File) assigned of 49/66 CNA genes RAF1 (16/26) and VHL (14/26) as G1 top-ranks with Fisher’s exact test p-values of 0.00228 and 0.0004437 (respectively) and SOS2 (7/20), HGF (4/20) and BRAF (3/20) as G3 top-ranks with p-values of 0.17, 0.51 and 0.075, respectively. The gene discussed is SOS2; the disease is renal cell carcinoma.