Of all CNA gene gains and losses, the PI3K-Akt Pathway enlisted 264 genes of which RAF1 (16 times lost), ITGA9 (15 times lost) and LAMB2 (15 times lost) were abundantly affected in HRO G1 ccRCC tumour samples. The gene discussed is ITGA9; the disease is nonpapillary renal cell carcinoma.