Comparing the tumour grades G1 and G3 in respect to gene losses, LIMD1-AS1 and SACM1L at 3p21.31 together with additional genes at 3p21.31, 3p21.1, 3p22.1, 3p22.3, 3p25.1 and 3p25.3 underscore that losses of these genes/chromosomal segments favour the establishment of grade G1 ccRCC tumours. This evidence concerns the gene SACM1L and neoplasm.