Twelve of them, including GNB2L1, MGAT1, RUFY1, RNF130, MAPK9, CANX, CNOT6, SQSTM1, LTC4S, TBC1D9B, HNRPH1, and FLT4 have been proposed as new ccRCC proto-oncogene candidates. The gene discussed is CANX; the disease is nonpapillary renal cell carcinoma.