In the present study, multiple regression analysis with presence or absence of EOS as the dependent variable and 25-OH D with the many other measures as independent variables revealed that the most important factors affecting EOS were gestational age, IL-6 and neonatal 25-OHD, supporting the strong relationship between EOS and the previous parameters as mentioned before, especially gestational age, which affects all other sepsis markers such as IL-6 and 25-OH vitamin D [26,27,31]. The gene discussed is IL6; the disease is Sepsis.