In humans, Byrne et al. [159] have shown that four weeks treatment of SBS patients with GH and glutamine positively aided intestinal compensation along with reducing requirement for parenteral nutrition, an effect which superseded glutamine supplementation alone and an effect that was maintained even after ending GH supplementation. Here, GH1 is linked to macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss.