HPSE and neoplasm: Using this in vitro angiogenesis assay that comprises heparanase and tumor microenvironment conditions, it was possible to screen potential anti-angiogenic candidates among the depolymerized and glycol split (RD-GS) HS mimicking compounds that we generated from UF-heparins, UF-dextranS and UF-λ-Carrageenan.