RHOC and neoplasm: It is also striking that there is more evidence suggesting that RhoC is more important than RhoA in promoting tumor cell invasion and metastasis (Clark et al., 2000, Dietrich et al., 2009, Hakem et al., 2005, Kitzing et al., 2010, Leung et al., 1996, Ridley, 2013, Ruth et al., 2006, Sahai and Marshall, 2002, Simpson et al., 2004).