RHOC and neoplasm: However, ROCK can also interact with the closely related GTPase RhoC, which is known to promote ameboid-based motility, tumor invasion, and metastasis (Clark et al., 2000, Hakem et al., 2005, Kitzing et al., 2010, Leung et al., 1996, Ruth et al., 2006, Sahai and Marshall, 2002, Simpson et al., 2004).