We previously demonstrated that microglia have decreased phagocytic functions in two mouse models of Alzheimer’s disease including the APP/PS1 mouse.54 Moreover, Krstic et al.25 showed that the offspring of Poly(I:C)-challenged dams are prone to develop an Alzheimer’s-like phenotype with aging, including increased levels of amyloid precursor protein and its proteolytic fragments, as well as mislocalization and hyperphosphorylation of tau in somatodendritic compartments. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.