APP and early-onset autosomal dominant Alzheimer disease: We have previously reported impairment in phagocytosis of microglia associated with plaques in the APP/PS1 model for Alzheimer’s disease using a bead-based phagocytosis assay similar what was used in the current study.54 It was also shown that immunotherapeutic amyloid clearance was less effective and microglia response altered when phagocytosis was impaired.81, 82 Thus, downregulation of functional microglial phagocytosis is a common feature in Alzheimer’s disease and MIA models.