APP and early-onset autosomal dominant Alzheimer disease: We previously demonstrated that microglia have decreased phagocytic functions in two mouse models of Alzheimer’s disease including the APP/PS1 mouse.54 Moreover, Krstic et al.25 showed that the offspring of Poly(I:C)-challenged dams are prone to develop an Alzheimer’s-like phenotype with aging, including increased levels of amyloid precursor protein and its proteolytic fragments, as well as mislocalization and hyperphosphorylation of tau in somatodendritic compartments.