Inspection of differentially expressed genes in the prefrontal cortex of Phf8 KO mice revealed upregulation of multiple serotonin receptors including Htr1b, Htr2a and Htr1a, which have previously been linked to anxiety and depressive phenotypes in rodents34, 35, 36, 37 (Fig. 5d). This evidence concerns the gene HTR1A and Anxiety.