MET and non-small cell lung carcinoma: The 89Zr-DFO-H2 cys-diabody showed a specific uptake in Hcc827-GR6 tumors (gefitinib-resistant human non-small-cell lung cancer (NSCLC) with high c-MET expression) that was higher than the uptake in Hcc827 (human NSCLC with low c-MET expression) tumors in PET scans at both 4 and 20 h p.i.; high-contrast images were obtained as early as 4 h p.i. In ex vivo biodistribution assays, at 4 h after injection, Hcc827-GR6 tumors had higher uptake levels at 1.8 ± 0.2%ID/g when compared to the negative control Hcc827 tumors at 0.65 ± 0.15%ID/g.