After validating the high affinity and specific binding of 18F-AH113804 to c-MET (Kd ≈ 2nM) by ex vivo analyses and PET imaging, Arulappu and colleagues demonstrated that 18F-AH113804-based PET imaging could detect loco-regional recurrences after surgical excision of orthotopically implanted HCC1954 human basal-like breast cancer with high c-MET expression in mice models as early as 6 days postoperatively, while with CT scanning, the recurrences could only be visualized after at least 20 days. The gene discussed is MET; the disease is breast carcinoma.