Plasmids carrying bioluminescent reporters for wild type c-MET (BMRwt) or c-METY530A (BMRmut) that turned OFF when c-MET was active/phosphorylated, and ON when c-MET was inhibited, were constructed and then stably transfected into human glioma cell lines D54 and U87-MG (both with c-MET expression) to assess their ability for detecting changes in c-MET expression. The gene discussed is MET; the disease is glioma.