In 2008, the team successfully visualized overexpressed c-MET in C6 (rat glioma) rat models in vivo by MRI based on a targeting contrast agent, anti-c-MET-Gd-DTPA-albumin, an anti-c-MET antibody linked to biotinylated Gd-DTPA-albumin [54]. Here, MET is linked to central nervous system cancer.