PET imaging performed in H441 bearing mice (human NSCLC with high c-MET expression) with a suitable concentration of the tracer revealed that tumor uptake peaked at 48 h p.i. (Fig. 4) and showed a significantly higher uptake of 89Zr-PRS-110 when compared to 89Zr-Tlc-PEG (non-c-MET binding), in line with the ex vivo biodistribution data (5.9 vs. 3.9%ID/g). Here, MET is linked to neoplasm.