HSPB6 and ischemia: Besides, the phosphorylation of HSPB6 at serine 16 was found to be required for attenuating ischemia/reperfusion-induced cell injury in mice, as the non-phosphorylatable HSPB6 induced apoptosis and necrosis, suppressed the autophagy activity, and subsequently depressed the cardiac functional recovery during ischemia and reperfusion (Qian et al. 2009).