Our findings that Shank2-deficient mice exhibit impaired learning and relearning in the delayed tasks are reminiscent of intellectual disability and the behavioral inflexibility often seen in autistic patients and may thus provide a useful experimental framework for evaluating the efficacies of potential therapeutic agents for the treatment of this disorder (Spooren et al., 2012; Jiang and Ehlers, 2013). Here, SHANK2 is linked to Intellectual disability.