IFNG and infection: Moreover, no significant perturbations in the ability of Mtb to induce a TNF-α, IL-1β, and IFN-γ-mediated proinflammatory response were detected in PBMCs infections, although MtbΔ33::33all3 and MtbΔ33::33all5 showed a slight decreased capacity to induce both TNF-α, and IL-1β (Figure 6B) secretion in line with what observed in MDMs infections.