ALT: Alanine aminotransferase; ANP: Atrial natriuretic peptide; BMI: Body mass index; BP: Blood pressure; CAD: Coronary artery disease; COR: Crude odds ratio; ECG: Electrocardiogram; HF: Heart failure; hs-CRP: High sensitivity C- reactive protein; IHD: Ischemic heart disease; LVH: Left ventricular hypertrophy; NAFLD: Non-alcoholic fatty liver disease; VHD: Valvular heart disease. The gene discussed is NPPA; the disease is heart valve disorder.