TNF and Behcet disease: The role of T lymphocytes in the pathogenesis of BD and the documentations of high serum levels of inflammatory cytokines in patients with active disease as well in aqueous samples of the eyes with activity has been postulated by many investigators, whereas tumor necrosis factor-alpha (TNF-α), an inflammatory cytokine, proved to have a role in the disease activity, which highlight the role of biologic agents, for example, infliximab as a promising treatment modality in intractable cases, through binding TNF-α and its soluble receptors [14, 15].