ACTN4 and prediabetes syndrome: Moreover, in a study performed in patients with prediabetes and type 2 DM, podocyte marker expression was higher in diabetic subjects as compared to those with prediabetes with regard to mRNA of nephrin, podocin, podocalyxin, synaptopodin, TRPC6, alpha actinin-4, and TGF-β1 [34].