TNF and rheumatoid arthritis: The downregulated differential gene pathways of Yang deficiency constitution after functional gathering presented mostly in signal transmission, for example, the TNF signaling pathway, NF-kappa B signaling pathway, FoxO signaling pathway, ErbB signaling pathway, MAPK signaling pathway, and the immune system pathway, for example, the NOD-like receptor signaling pathway, rheumatoid arthritis, toll-like receptor signaling pathway, inflammatory bowel disease (IBD), and intestinal immune network for IgA production (Figure 5).