NCR3 and chronic myelogenous leukemia, BCR-ABL1 positive: Similarly, the natural cytotoxicity receptors NKp30 and NKp46, the latter characterized as the major triggering receptor involved in NK cell cytotoxicity (39) and the killer immunoglobulin-like receptors (KIRs) KIR2DL2/DL3/DS2 were downregulated in CML patients at diagnosis compared to healthy donors.