IFNA1 and chronic myelogenous leukemia, BCR-ABL1 positive: Based on what is known regarding NK cell frequency in TFR, trials are underway using pharmacological manipulation, such as lenalidomide, which stimulates NK cells and enhances antitumor responses, in combination with TKI to further augment TFR success in CML (ACTRN12615001169538), or using IFN in combination with a second-generation TKI such as nilotinib (NCT02001818) to enhance immune-modulation prior to a TFR attempt.