CD8A and neoplasm: Myeloid-derived suppressor cells also mediate the recruitment and expansion of immunosuppressive Treg, a specialized type of CD4+ T cell expressing the transcription factor forkhead box P3 (FoxP3), that can compromise the function of antitumor effector CD4+/CD8+ T cells and antigen-presenting cell activity to facilitate tumor cell immune evasion (62, 71–77).