What is more, the PD-L1 expression could dynamically increase in response to the interferon-γ (INF-γ) released from CD8+ T cells in tumor microenvironment as an adaptive immune resistance (47), and this seems to be more common than the constitutive expression of PD-L1 in most cancer histologies (48, 49). The gene discussed is CD8A; the disease is neoplasm.