IL6 and cancer: Underlying mechanisms of TLR4 triggering may include the NADPH oxidase 1-dependent ROS pathway, TLR4/ROS/microRNA-21 pathway, mitogen-activated protein kinase (MAPK) and nuclear factor kappa beta (NFκB) pathway, and autophagy of cancer cells to facilitate production of pro-inflammatory and immunosuppressive cytokines, chemokines, and matrix metallopeptidase such as IL-6, IL-8, transformation growth factor-β, vascular endothelial growth factor, chemokine (c-c motif) ligand 2, chemokine (c-c motif) ligand 20, MMP2, and so on (34, 36, 37).