NUCB2 and Anorexia: The anorexia-related actions of nesfatin-1 result from oxytocin and melatonin signaling in several hypothalamic and medullary anorexigenic pathways (Oh et al., 2006; Maejima et al., 2009; Stengel et al., 2009b; Yosten and Samson, 2009).