SCN1A and epilepsy: In addition, and correlating with the predominant localization of Nav1.1 in the AIS of GABAergic neurons (Ogiwara et al., 2007; Lorincz and Nusser, 2008; Catterall et al., 2010; Tian et al., 2014), the loss of proper localization and function of Nav1.1 is considered to be a factor for the onset of epilepsy caused by a disruption of the inhibitory balance in the brain (Catterall et al., 2010).