To advance knowledge of HSPA6, we investigated whether it is targeted to stress-sensitive neuronal sites with components of a protein disaggregation/refolding machine in human neuronal SH-SY5Y cells that have been previously used as a model in studies of neurodegenerative diseases (Grynspan et al., 1997; Imamura et al., 2006; Ross and Spengler, 2007; Cheung et al., 2008; Plowey et al., 2008; Krishna et al., 2014). Here, HSPA6 is linked to neurodegenerative disease.