AZD8055 and MK2206 decreased Cyclin D2, D3 and E in Rh30 cells whereas rapamycin also decreased both Cyclin D2 and D3 but not Cyclin E (Cyclin D2 and Cyclin D3 are the major G1 phase cyclins in rhabdomyosarcoma, Shen and Houghton, unpublished). This evidence concerns the gene CCNE1 and rhabdomyosarcoma.