CD8-KO animals infected with LM-PLP after established EAE exhibited similar clinical disease to those infected with LM-OVA or given saline with comparable disease onset, peak, mortality, and CDI parameters (Fig. 4B), indicating that LM-PLP treatment of ongoing EAE was also mediated through the induction of autoregulatory CD8 T cell responses. This evidence concerns the gene CD8A and clostridium difficile infection.