Among them, 3 functional variations [14–16] in the TLR1 (rs5743551, -7202A>G), TLR2 (rs7656411, 22215G>T) and TLR4 (rs11536889, +3725G>C) genes with high (>0.2) minor allele frequencies in the Asian population were retrospectively investigated to determine their associations with transplant outcomes in a cohort of patients who underwent unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program (JMDP). This evidence concerns the gene TLR2 and hematologic disorder.