BRD4 and central nervous system cancer: BRD4 belongs to the BET (bromodomain and extraterminal domain) subfamily of bromodomain-containing proteins comprised of Brd2, Brd3, Brd4, and Brd5.BRD4 protein is elevated in gliomas and has been demonstrated to regulate transcriptional activation of various genes involved in sustaining growth and developmental of tumors, and therefore, drugs targeting BET show potential therapeutic intervention.