Western blot analysis confirmed that, following treatment with PES or PET-16, the level of PABPC1 was notably decreased in the mitochondrial fraction of H1299 lung carcinoma cells as well as in 1205Lu melanoma cells; in each case, there was a much more modest decrease in the abundance of cytosolic PABPC1 (Figure 7A). This evidence concerns the gene PABPC1 and melanoma.